Ibutamoren Mesylate (MK677) Description
Ibutamoren mesylate (MK-677) is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. Ibutamoren mesylate (MK-677) also alters metabolism of body fat and so may have application in the treatment of obesity.
Ibutamoren Mesylate(MK677)Specifications
Product Name |
Ibutamoren Mesylate(MK677) |
Chemical Name |
MK-677;2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate; |
Brand Name |
Ibutamoren Mesylate(MK677) |
Drug Class |
SARMs(Selective androgen receptor modulator) |
CAS Number |
159752-10-0 |
InChIKey |
DUGMCDWNXXFHDE-VZYDHVRKSA-N |
Molecular Formula |
C27H36N4O5S.CH4O3S |
Molecular Weight |
624.768 g/mol |
Monoisotopic Mass |
624.229 g/mol |
Melting Point |
161 to 315ºC |
Boiling Point |
868.9 °c at 760 mmhg |
Biological Half-Life |
4-6 hours |
Color |
white to beige |
Solubility |
H2O: soluble5mg/mL, clear |
Storage Temperature |
2-8°C |
Ibutamoren Mesylate Application |
Growth hormone releasing factor; alters metabolism of body fat; increase both muscle mass and bone mineral density; alters metabolism of body fat |
Ibutamoren Mesylate (MK677) (159752-10-0) video
https://vimeo.com/309399626
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